Informatics Publishing Limited

Mohd. Yaqub Khan ¹, Poonam Gupta ¹, Bipin Bihari ¹, Vikas Kumar Verma ¹

Affiliations
1 Saroj Institute of Technology and Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow- 226002,Uttar Pradesh, IN

Abstract

The current approach to the treatment of both type 1 and type 2 diabetes is to achieve the best possible glucose control. Past clinical trials have shown that glycemia plays a key role in the prevention of both macro- and microvascular complications. During the past 20 years, a number of new medications to control blood glucose have been introduced, and new approaches to the use of older medications have been developed. Weight and diabetes, especially type 2 diabetes, are closely related. Obesity is a major risk factor for the development of type 2 diabetes, and the current increase in obesity in our society has fueled a major increase in the expression of this disease. Not only does weight, through the mechanism of insulin resistance, aggravate hyperglycemia, it also increases the risk for hypertension, hyperlipidemia, and other conditions that lead to cardiovascular disease.

Keywords

Glycemia, Obesity, Hyperglycemia, Hypertension, Hyperlipidemia

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Poonam Gupta ¹, Mohd. Yaqub Khan ¹, Vikas Kumar Verma ¹, Ashish Pathak ¹

Affiliations
1 Saroj Institute of Technology & Management, Ahimamau , P.O. Arjunganj , Sultanpur Road, Lucknow-226002, Uttar Pradesh, IN

Abstract

Medicinal plants continue to play a central role in the healthcare system of large proportions of the world's population. This is particularly true in developing countries, where herbal medicine has a long and uninterrupted history of use. Continuous usage of herbal medicine by a large proportion of the population in the developing countries is largely due to the high cost of Western pharmaceuticals and healthcare. Every year, millions of people are diagnosed with cancer, leading to death in a majority of the cases. Specific part of it is formulated into suitable preparations compressed as tablets or made into pills, used to make infusions, extracts, tinctures, etc., or mixed with excipients to make lotions, ointments, creams, etc. Few herbal drugs are subject to legislative control. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide, S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin, 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears), silymarin (milk thistle), anethol, catechins, eugenol, indole-3-carbinol, limonene, beta carotene, and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents, but also novel lead compound and potentially relevant mechanisms of action.

Keywords

Herbal Medicine, Pharmaceuticals, Healthcare, Infusions, Extracts, Tinctures, Anticancer Agents

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Mohd. Yaqub Khan ¹, Poonam Gupta ², Vinod Kumar Singh ², Sanjay Yadav ², Vikas Kumar Verma ²

Affiliations
1 Saroj Institute of Technology & Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow-226002,Uttar Pradesh
2 Saroj Institute of Technology & Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow-226002,Uttar Pradesh, IN

Abstract

Out of the 1114 strains belonging to 29 genera and 105 species of microbes (molds, yeasts and bacteria) isolated from different sources [clinical cases, environment (water, air, soil, droppings of lizards and birds), food and healthy animals], 38.2% were sensitive to lemongrass oil discs containing 50 μg oil/disc. All molds, yeasts, Lactobacillus acidophilus, Morganella morganii, most of the Bacillus spp. Strains (84.3%), aeromonads (78%), Edwardsiella spp. (73.9%), 53.6% pseudomonads, 53.1% streptococci and 50% of Budvicia aquatica and Leminorella ghirmontii strains were sensitive to lemongrass oil (LGO). On the other hand, all Hafnea alvei, Laclercia adecarboxylata, Xenorhabdus luminescens and majority of Salmonella enterica (98.3%), Citrobacter spp. (93.7%), Providencia spp. and Kluyvera cryocrescens (83.3%), Enterobacter spp. (78.2%), Proteus spp. (78%), Escherichia spp. (77.7%), enterococci (73.7%), Serratia spp. (75%) and Erwinia ananas (75%), Pragia fontium (70.6%), staphylococci (69.8%) and Klebsiella spp. (62.7%) strains were resistant to LGO. MIC of LGO for sensitive strains (tested against discs containing 50 μg LGO) varied from 1 μg to 32 μg /ml while none of the resistant strains had MIC <64 μg LGO/ ml. MIC for yeast strains was the least i.e., 1 μg LGO/ ml. LGO had microbicidal activity on E. coli, S. aureus and Candida albicans. LGO instantly killed C. albicans and E. coli, and S. aureus in 10 min at 1 mg/ ml concentration, indicating of its wide spectrum antimicrobial activity at easily achievable concentrations. Study also indicated that LGO is more effective on enterococci in aerobic instead of microaerophilic growth conditions, it is indicative that in-vivo sensitivity results may differ from in-vitro tests.

Keywords

Lemongrass Oil, Antimicrobial Activity, Microbes, Microaerophilic Growth

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